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All tagged Twist Bioscience
Twist Exome 2.0: A new and powerful exome panel with best-in-class performance for translational research and more
Synthetic biology is the practice of redesigning natural biological systems for useful purposes. Through synthetic biology, researchers can engineer microorganisms to consume environmental pollutants or aid in the manufacturing of sustainable fuels. The potential benefits of synthetic biology are many and profound, but in the wrong hands, while very rare, the tools of synthetic biology could be used to cause harm. As such, the scientific community must take special care to develop safeguards that prevent the misuse of these tools without suppressing growth and innovation in this dynamic field.
In the milieu of rushing blood, plasma, and cells, small wayward bits of DNA are easy to overlook. But stored within these scraps of genetic material, known as cell-free DNA (cfDNA), is information offering the earliest glimpses of cancer development. Being able to detect and understand these signals could dramatically improve our ability to detect and treat cancer before the disease has developed.
Read about Twist Biopharma's development of antibody candidates against GPCR therapeutic targets ADORA2A and GLP1R
In building towards a greener future, Twist Bioscience has built sustainability into its DNA synthesis platform. Through miniaturized chemistry, Twist enables massive scaling of the DNA synthesis process while also greatly reducing the company’s chemical footprint. But, to truly work towards a sustainable future, laboratories have to go beyond their products to address the challenge of sustainable science.
98% of the human genome consists of non-protein-coding DNA, much of which has unknown functions. Nonetheless, noncoding DNA houses important genetic elements that can alter gene expression levels through genetic and epigenetic means, such as enhancers, silencers, promoters, and other so-called regulatory elements. The average protein-coding gene is governed by multiple non-coding regulatory elements whose activity can vary in a context-dependent manner, making it exceedingly difficult to both identify these elements and link them to the transcriptional activity of specific genes. Without a detailed understanding of these regulatory elements, potentially clinically relevant information coded within the growing influx of genetic data will remain undiscovered. To help convert data into knowledge, researchers are turning to Massively Parallel Reporter Assays (MPRAs).
Get the highlights from a recent DDW podcast and learn about Twist Biopharma’s antibody development services, partnerships, and process
RNA-seq is an essential research tool that holds exciting prospects for the early detection of cancer. However, in clinical samples highly abundant mRNA and rRNA sequences obscure rarer RNA subtypes that may hold the keys to early cancer detection, such as long non-coding RNA. Here we dive into recent research from the University of Ghent outlining the use of targeted RNA-seq to enrich lncRNA from various sample types and discuss how recent advances make target enrichment an invaluable tool for high-resolution RNA-seq experiments.
In this article, we highlight how quality library preparation reduces sequencing error rates while providing high-yield sequencing libraries. Twist has just upgraded its suite of library preparation tools by creating the Library Preparation Enzymatic Fragmentation (EF) Kit 2.0. We detail how this kit has been built to help you achieve better quality library preparation for better sequencing results.
